Monoamine and diamine Organic salts, Salts and Salts and monoaminoacido diaminoacido, ether and diaminoacido monoaminoacido precursor combretastina a-4 phosphate

摘要

Refers to precursors of Combretastatin a-4; formula I where one of OR1, OR2 is o (-) QH (+) and the other is ohOr (-) + (QH); Q is an Amine with an organic nitrogen with a Proton to form a cation QUATERNARY AMMONIUM, amino acid with at least 2 nitrogens,Where one of the nitrogens together with a Proton to form a QUATERNARY AMMONIUM cation QH (+); The amino acid histidine, Lysine, arginine, tryptophan,Ornithine; all groups of carboxylic acid is in the form of amino acid Esters.It also relates to a method for preparing a Composition and where the PH is adjusted by a different Agent Sodium hydroxide: salts of the compounds are precursors of combrEtastatina and have better Physicochemical Properties such as higher solubility, Lower hygroscopicity,Greater stability and may be useful to modulate the growth and metastasis of a tumor in an animal