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Estradiol Derivatives with a non Aromatic Substituent in position 11 of the steroid that has Affinity for the estrogen receptor
Estradiol Derivatives with a non Aromatic Substituent in position 11 of the steroid that has Affinity for the estrogen receptor
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机译:在类固醇的11位上具有非芳香族取代基的雌二醇衍生物,对雌激素受体具有亲和力
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摘要
Refers to estrogenic steroid of formula I, wherein R1 is H, alkyl acyl C1 - C3, C2 and C3; R2 is H, or C1 - C4 alkyl, or - or - alquenilo c2-c4, alquinilo c2-c4; R3 is H, c1-c4 alkyl, alquenilo c2-c4,Alquinilo c2-c4 at position 15 or 16; R4 is H, alkyl alquenilo C1 - C5, C2 - C5, C2 - C5 alquinilo optionally substituted by Halogen, etinilo; R5 C1 - C3 is H, alkyl,Acyl C2 - C3 alkyl; R4 is C1 - C5, C2 - C5 alquenilo alquinilo C5, C2, C1 - C5 alquilideno optionally substituted by Halogen, alquiloxi C1 - C3.The Compound has an affinity for the estrogen receptor and may be useful for the treatment of disorders related to estrogen deficiency and menopause, osteoporosis,Contraceptive, Alzheimer's disease, Breast tumor, Prostate hypertrophy
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