Cinnamon receptor modulator, its preparation process and use of cinnamon receptor modulator in the treatment of respiratory and non respiratory diseases

摘要

It refers to the use of a CB2 cannabinoides receiver to block the activation of pulmonary epithelial cells and treat respiratory diseases, such as chronic pulmonary obstructive disorder, emphysema, asthma, bronchitis, which is related to the activation of leukocytes in formula one, where a and B are C, N; X ring is Pyrethroid and pyrrolazole; when a is n, C (= O) nr1r2 and C3 and R5 are combined, they do not exist; when a is C, C is C, C is C, nr1r2 and R5 are a, while the other is a, C is C, 2 is B, 2 is C4, B and C5 are combined to form arilo, and the alternative heteromorphic substitutes are R6, f is 0-1, G is 1-2, R1 and R2 are h, heteromorphic.Propyl isopropyl isopropyl isopropyl isopropyl isopropyl R8 and R9 include, inter Alia, h, asphalt, isopropene and others; R10 is asphalt, isopropene, alquenilo, asphalt, etc. It also refers to a second-order benzo concentrated compound; q is n, Cr6, a j, K, l, M is C, the rest is n.