Pyridine derivatives as antagonists of neuroreceptors

摘要

It refers to a formula based pyridine derivative, wherein R1 and R2 are tar, cyclopentyl compound, aralquilo or R1 and R2 are h, and the other is tar, amino or cyclopentyl; R1 and R2 form an acyclic ring of 4 to 10 members together with N; R3 is cyclopentadiene tar, alcohole, alcoxyl, alcoxyl, alcohole, Among them, R4 is arilo, wherein R4 is non nitrosulfonyl or nitroisoyl; A1 and A2 are ch, N. preferred compound (E) - 4-methyl-6-pirrolidin-1-il-2 - [2 - (3-trifluoromethyl-phenyl) - ethylene] - pirimidine (E) - 2 - [2 - (2 - (4-dichloro-phenyl) - ethylene] - 4-methyl-6-pirrolidin-1-pirimidine,There are others He also mentioned a process of drug preparation and synthesis. These compounds are antagonistic substances for nerves and (NPY) receptors and are used in the treatment of arthritis, diabetes and obesity.