4-phenylpyridine as a derivative of NK-1 neuroreceptor antagonist

摘要

It refers to the derivative of 4-pyridine-1, wherein R is h, halogen, R1 is (C = C) MR1 ',（CR'=CR）Mr1'；R1 is halogen, cyanide, (c) Mr'r "R5; conr'r,, HC, HC, HC, HC, HC, HC, HC, HC, HC Alcox; R and R2, R4 and r4'son HC = CH-CH = ch are substituted by halide, Alcoy; X is conr8, (CH2) Po, nr8co, among others; n is 1-2; m is 0-4; or P is 1-2. They are the preferred compounds of N - (3,5-bis-trifluoromethyl-benzene) - 6 - (4-hydroxy-pyridine-1-ilo) - n-methyl-4-o-methanol-nicotine,N - (3,5-difluorooctane sulfonic acid benzene) - 6-chloro-n-methyl-4-o-methanol-nicotine, etc.; it also relates to a preparation procedure. These compounds are antagonistic to NK-1 neurohormone receptor and can be used to treat rheumatoid arthritis, asthma, intestinal inflammation and central nervous system modulation.