NOVEL SUBSTITUTED DERIVATIVES OF CINAMOYL GUANIDINE, METHOD OF OBTAINING THEM, THEIR APPLICATION IN PRODUCTION OF PHARMACEUTIC AND DIAGNOSTIC AGENTS AND PHARMACEUTIC AGENT AS SUCH

摘要

Substd. cinnamic acid guanidides of formula (I) and their salts are new: at least one of R1-R5 = XaYbLnU; X = CR16R17, O, S or NR18; a = 0-1; Y = 1-8C alkenyl, 1-8C alkenyl-T, 1-8C alkenyl-T2; T = NR20, O, S or phenyl (opt. substd. by 1-3 F, Cl, CF3, CH3, OCH3 or NR21R22); b = 0-1; L = O, S, NR23 or CkH2k; k = 1-8; n = 0-1; U = NR24R25 or 1-9C N-heterocycle with a N- or C- bridge and opt. substd. by 1-3 F, Cl, CF3, CH3, OCH3 or NR27R28; R24, R 25 = H, 1-8C alkyl or 1-8C perfluoroalkyl; or R24+R25 = (CH2)x with one CH2 opt. replaced by O, S, NH, NMe or N-benzyl; the remaining R1-R5 = H, F, Cl, Br, I, CN, OnCmH2m+1, Op(CH2)sCqF2q+1 or CrH2rR10; m = 0-8; p = 0-1; q = 1-8; s, r = 0-4; R10 = 3-8C cycloalkyl or phenyl opt. substd. by 1-3 F, Cl, CF3, CH3, OCH3 or NR11R12; R6, R7 = H, F, Cl, Br, I, CN, 1-8C alkyl, 1-8C perfluoroalkyl, 3-8C cycloalkyl, phenyl substd. by 1-3 F, Cl, CF3, CH3, OCH3 or NR14R15; and R11, R12, R14-R18, R20-R23, R27 and R28 = H, 1-4C alkyl or 1-4C perfluoroalkyl.