NAFTALEN DERIVATIVES AS PROSTAGLANDIN I2 AGONISTS

摘要

A compound or the formula: IMAGE wherein R1 is carboxy or protected carboxy, R2 is hydrogen, hydroxy or protected hydroxy, R3 is hydrogen, hydroxy, protected hydroxy, etc., R4 is hydrogen or halogen, A1 is lower alkylene, A2 is bond or lower alkylene, -R5 is IMAGE (in which R6 is mono(or di or tri)aryl(lower)alkyl and Z is N or CH), etc., and IMAGE etc., and a pharmaceutically acceptable salt thereof which are useful as medicaments.