LINEAR POLYAMINS SUBST. With PIPERIDINYL-2-ALKYL FOR THE REDUCTION OF INTRACELLULAR ENDOGENEOUS POLYAMINE LEVELS AS PUTRESCINE SPERMIDINE AND SPERMINE AND ITS IMPACT ON CELLULAR PROLIFERATION

摘要

PCT No. PCT/EP96/00898 Sec. 371 Date Sep. 15, 1997 Sec. 102(e) Date Sep. 15, 1997 PCT Filed Mar. 4, 1996 PCT Pub. No. WO96/28425 PCT Pub. Date Sep. 19, 1996The invention relates to compounds of formula (I) IMAGE (I) wherein either R1 is hydrogen and R2 is lower alkyl lower alkenyl or lower alkynyl, m is 3 or 4 and n is 2 or 3; or R1 and R2 together are tetrainethylene, m is 3 or 4 and n is 2; or salts thereof. The compounds of formula (I) influence polyamine biosynthesis and have antiproliferative activity as well as an action against protozoans.