PIPERIDINYL-2-ALKYL SUBST. LINEAR POLYAMINES FOR THE REDUCTION OF INTRACELLULAR, ENDOGENIC POLYAMINE LEVELS SUCH AS PUTRESCINE, SPERMIDINE AND SPERMINE, AND THEIR IMPACT ON CELL PROLIFERATION

摘要

The invention relates to compounds of formula (I), whereineither R1 is hydrogen and R2 is lower alkyl, lower alkenyl or loweralkynyl, m is 3 or 4 and n is 2 or 3; or R1 and R2 togetherare tetramethylene, m is 3 or 4 and n is 2; or salts thereof.The compounds of formula (I) influence polyamine biosynthesisand have antiproliferative activity as well as an action againstprotozoans.