BENZOXAZINONES, PHARMACEUTICAL COMPOSITION (VARIANTS), COMBINATION OF COMPOUNDS (VARIANTS), METHOD FOR INHIBITION OF HIV REVERSE TRANSCRIPTASE, METHOD FOR PREVENTING OR TREATING HIV INFECTIONS

摘要

Certain benzoxazinones of the formula: wherein: X is halo, X1 is trihalomethy, or pentahaloethyl; Z is O; are useful in the inhibition of HIV reverse transcriptase (including its resistant varieties), the prevention or treatment of infection by HIV and the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described.