TRICYCLIC INHIBITORS OF POLYMERASE POLY(ADF-RIBOSE) FOR THE TREATMENT OF CANCER AND INHIBITING NEUROTOXICITY, USE THEREOF AND A PHARMACEUTICAL COMPOSITION BASED THEREON

摘要

Compounds of formula (I) are poly(ADP-ribosyl)transferase (PARP) inhibitors, and are useful as therapeutics in treatment of cancers and the amelioration of the effects of stroke, head trauma, and neurodegenerative disease. As cancer therapeutics, the compounds of the invention may be used, e.g., in combination with cytotoxic agents and/or radiation.