A HUMANIZED ANTIBODY BEING ASSOCIATED WITH BETA-AMYLOID PEPTIDE ((A?- POLYNUCLEIC ACID CODING IT, A PHARMACEUTICAL COMPOSITION CONTAINING IT, AND USE OF SAID HUMANIZED ANTIBODY FOR MAKING MEDICINAL AGENT FOR PROPHYLAXIS AND TREATMENT OF STATES ASSOCIATED WITH FORMATION OF BETA-AMYLOID PLAQUES

摘要

The invention relates to humanized antibodies being associated with beta-amyloid peptide (A?), and polynucleic acids coding them. Also disclosed is a pharmaceutical composition containing said antibodies, and use of said humanized antibodies for making medicinal agent for prophylaxis and treatment of states associated to formation of beta amyloid plaques, in particular for the treatment of clinical or preclinical Alzheimer's disease, DownÆs syndrome, clinical or preclinical form of cerebral amyloid angiopathy or for the treatment, prevention or reversing deterioration of perceptive activity insaid diseases.