PHOTOSENSIBILIZER CONTAINING A PHTALOCIANINE DERIVATIVE FOR PHOTODYNAMIC TUMOR THERAPY.

摘要

FORMULA COMPOUNDS ARE SUBMITTED (I) THAT ARE USEFULLY EMPLOYED IN PHARMACEUTICAL COMPOSITIONS BOTH MIXED AS IN ASSOCIATION WITH A CARRIER OR A PHARMACOLOGICALLY ACCEPTABLE DILUENT; WHERE M IS A DIAMAGNETIC METAL ATOM OR A DIAMAGNETIC OR SILICON METAL COMPOSITE OR A SILICON COMPOUND OR IS 2H; H IS UNITED TO EACH OF THE TWO NITROGEN ATOMS REPRESENTED AS UNITED TO M (POSITIONS 29 AND 31 SHOWN); R1 TO R25 ARE EQUAL OR DIFFERENT AND ARE SELECTED INDEPENDENTLY BETWEEN RENT C {SUB, 1-20}, ALQUENILO C {SUB, 220}, XOY, (A), X {SP, 2} COOX {SP, 1}, X {SP, 2} CONR1R11 YH; WHERE XYX {SP, 2} IS SELECTED INDEPENDENTLY BETWEEN A CHEMICAL LINK, - (CH {SUB, 2}) {SUB, N} - WHERE N IS A WHOLE BETWEEN 1 AND 20 AND - (CH {SUB, 2} {SUB, A} CH = CH (CH {SUB, 2}) {SUB, B} WHERE A AND B ARE SELECTED INDEPENDENTLY BETWEEN 0-20 YA + B VALID BETWEEN 0 AND 20; X {SP, 1} SELECTED INDEPENDENTLY BETWEEN RENT C {SUB, 1-20}, RENT C {SUB, 2-20} YH, R1 AND R11 SELECTED INDEPENDENTLY BETWEEN H, RENT C {SUB, 1-20}, RENT C {SUB, 2-20 }, - (CH {SUB, 2}) {SUB, N} -; AND IS SELECTED INDEPENDENTLY BETWEEN RENT C {SUB, 1-20}, RENT C {SUB, 220} YH; TAKING INTO ACCOUNT THAT NOT ALL R1- R25 ARE SIMULTANEOUSLY H. THE COMPOUNDS OF FORMULA (I) CAN ALSO BE USED FOR THE PREPARATION OF A MEDICINAL PRODUCT FOR PHOTODYNAMIC THERAPY.