METHOD FOR IDENTIFYING COMPOUNDS FOR INHIBITION OF NEOPLASTIC LESIONS, PHARMACEUTICAL COMPOSITIONS FROM SUCH COMPOUNDS AND USES OF SUCH COMPOUNDS AND COMPOSITIONS FOR TREATING NEOPLASTIC LESIONS

摘要

This invention provides a method to identify compounds potentially useful forthe treatment of neoplasia in mammals. The phosphodiesterase inhibitoryactivity of acompound is determined along with COX inhibitory activity. Growth inhibitoryandapoptosis inducing effects on cultured tumor cells are also determined.Compounds thatexhibit phosphodiesterase inhibiton, growth inhibition and apoptosisinduction, but notsubstantial prostaglandin inhibitory activity, are desirable for the treatmentof neoplasia.Such compounds are useful for pharmaceutical compositions and uses fortreatingneoplasia.