METHOD FOR IDENTIFYING COMPOUNDS FOR INHIBITION OF NEOPLASTIC LESIONS, PHARMACEUTICAL COMPOSITIONS FROM SUCH COMPOUNDS AND USES OF SUCH COMPOUNDS AND COMPOSITIONS FOR TREATING NEOPLASTIC LESIONS

摘要

There is disclosed the use of a compound in the manufacture of a medicament for treating neoplasia, wherein said compound is identified by determining the cyclooxygenase inhibitory activity of the compound; and determining the cGMP-specific PDE inhibition activity of the compound by evaluating that activity against cGMP-specific PDE enzymatic activity; wherein cyclooxygenase inhibitory activity lower than inhibitory activity of said cGMP-PDE activity is indicative that the compound has potential for treating neoplasia.