首页> 外国专利> DIHYDROIMIDAZO4,5-EINDOLE AND 7H-PYRROLO3,2-FQUINOXALINEDERIVATIVES AS NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS AND/OR SEROTONERGICLIGANDS

DIHYDROIMIDAZO4,5-EINDOLE AND 7H-PYRROLO3,2-FQUINOXALINEDERIVATIVES AS NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS AND/OR SEROTONERGICLIGANDS

机译:二羟基咪唑啉[4,5-E]吲哚和7H-吡咯啉[3,2-F]喹喔啉衍生物作为烟碱乙酰胆碱受体配体和/或血清素配体

摘要

Compounds of the formula (I) in which R1, R2, R3 and R4 are as defined in Claim 1, are ligands of the nicotinic acetylcholine receptor and/or serotonergic ligands and are suitable for the prophylaxis or treatment of psychoses, schizophrenia, depression, anxiety states, dementia, in particula r Alzheimer's disease and Lewy bodies dementia, neurodegenerative disorders, Parkinson's disease, amyotrophic lateral sclerosis, Huntington's disease, Tourette's syndrome, learning and memory restrictions, bulimia, anorexia nervosa or other eating disorders, compulsive behaviour, premenstrual syndrome, age-induced memory impairment, amelioration of withdrawal symptoms in nicotine dependence. Strokes or brain damage by toxic compounds, and for the treatment of disorders which are characterised by an excess of circulati ng serotonin or by serotonergic hyperactivity.
机译:其中R 1,R 2,R 3和R 4如权利要求1所定义的式(I)化合物是烟碱乙酰胆碱受体和/或5-羟色胺能配体的配体,并且适合于预防或治疗精神病,精神分裂症,抑郁症,焦虑状态,痴呆,特别是阿尔茨海默氏病和路易体痴呆,神经退行性疾病,帕金森氏病,肌萎缩性侧索硬化症,亨廷顿氏病,图雷特氏综合症,学习和记忆障碍,贪食症,神经性厌食症或其他饮食综合症,强迫性行为,经前,年龄引起的记忆障碍,尼古丁依赖中戒断症状的缓解。中毒性化合物对中风或大脑的损害,以及用于治疗以循环5-羟色胺过多或血清素能亢进为特征的疾病。

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