Desoxyribonucleic acids coding for the equine ige-allotype heavy chain constant region, the recombinant immunoglobulin obtained therewith and corresponding isotype-specific monoclonal antibodies and the utilization thereof

摘要

The invention relates to novel equine Cepsilon?a custom-character file="US20040115764A1-20040617-P00900.TIF" wi="20" he="20" id="custom-character-00001"/and Cepsilon?b custom-character file="US20040115764A1-20040617-P00900.TIF" wi="20" he="20" id="custom-character-00002"/genes coding for IgE-allotypes heavy chain constant regions and used in the production of IgE-isotype recombinant immunoglobulin. Said recombinant immunoglobulins represent valuable auxiliary agents for IgE-diagnosis, especially equine allergy diagnosis. With the aid of the recombinant IgEs, antibodies are obtained that can be used in allergy diagnosis, inter alia, in ELISA-based test kits.