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Desoxyribonucleic acids coding for the equine ige-allotype heavy chain constant region, the recombinant immunoglobulin obtained therewith and corresponding isotype-specific monoclonal antibodies and the utilization thereof
Desoxyribonucleic acids coding for the equine ige-allotype heavy chain constant region, the recombinant immunoglobulin obtained therewith and corresponding isotype-specific monoclonal antibodies and the utilization thereof
The invention relates to novel equine Ca and Cb genes coding for IgE-allotypes heavy chain constant regions and used in the production of IgE-isotype recombinant immunoglobulin. Said recombinant immunoglobulins represent valuable auxiliary agents for IgE-diagnosis, especially equine allergy diagnosis. With the aid of the recombinant IgEs, antibodies are obtained that can be used in allergy diagnosis, inter alia, in ELISA-based test kits.
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机译：本发明涉及新颖的马Ca <图像文件=“ US20040115764A1-20040617-P00900.GIF” he =“ 20” id =“ custom-character-00001” imgContent =“ undefined” imgFormat =“ GIF” wi =“ 20” / >和Cb <图像文件=“ US20040115764A1-20040617-P00900.GIF” he =“ 20” id =“ custom-character-00002” imgContent =“ undefined” imgFormat =“ GIF” wi =“ 20” />为IgE异型重链恒定区，用于IgE同型重组免疫球蛋白的生产。所述重组免疫球蛋白代表了用于IgE诊断，特别是马变态反应诊断的有价值的辅助剂。借助于重组IgE，获得了可用于过敏诊断，尤其是在基于ELISA的测试试剂盒中的抗体。
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