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Conjugated peptide nucleic acids having enhanced cellular uptake
Conjugated peptide nucleic acids having enhanced cellular uptake
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机译:具有增强的细胞摄取的共轭肽核酸
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摘要
Peptide nucleic acids conjugated to lipophilic groups and incorporated into liposomes exhibit enhanced cellular uptake and distribution. Cellular uptake and distribution of peptide nucleic acids also increases with the introduction of an amino acid side chain into the backbone of peptide nucleic acids. Methods of modulating cellular uptake and methods for treating animals are provided. The peptide nucleic acids of the invention comprise naturally-occurring nucleobases and non-naturally-occurring nucleobases attached to a polyamide backbone.
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