USES OF OUABAIN AND OUABAIN-LIKE MOLECULES IN APOPTOSIS RELATED PATHOLOGIES

摘要

The inventation describes the use of ouabain or an ouabain-like molecule for protection against apoptosis in various organs or tissues. The compound acts by inhibiting the Na+, k+ pump, thereby inverting the physiologically low intracellular Na+/k+ ratio required for progression of apoptosis (e.g. in VSMC). Therefore, the molecule can be used to treat disorders of diseases due to increased apoptosis, such as cardiopathies myocardial ischemia/angina, infarct or infection, congestive heart failure, cns or neurodegenerative disorders, trauma, reperfusion injury, severe burn or renal failure.