DEPLETION OF CELLULAR COENZYME-A LEVELS AS A MEANS TO SELECTIVELY KILL CANCER CELLS

摘要

The invention describes a method to inhibit growth or kill cancer cells by acute depletion of free cellular Coenzyme A (CoA). This invention encompasses: any method to selectively decrease CoA in cancer cells by increasing the utilization of CoA and/or reducing its synthesis. As demonstrated herein, depletion of free CoA may be accomplished by inhibiting fatty acid synthase (FAS). This invention also includes depletion of free cellular Coenzyme A by interventions in addition to or alternative to FAS inhibition.