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DEPLETION OF CELLULAR COENZYME-A LEVELS AS A MEANS TO SELECTIVELY KILL CANCER CELLS
DEPLETION OF CELLULAR COENZYME-A LEVELS AS A MEANS TO SELECTIVELY KILL CANCER CELLS
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机译:消耗细胞辅酶A水平作为选择性杀死癌细胞的一种手段
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摘要
The invention describes a method to inhibit growth or kill cancer cells by acute depletion of free cellular Coenzyme A (CoA). This invention encompasses: any method to selectively decrease CoA in cancer cells by increasing the utilization of CoA and/or reducing its synthesis. As demonstrated herein, depletion of free CoA may be accomplished by inhibiting fatty acid synthase (FAS). This invention also includes depletion of free cellular Coenzyme A by interventions in addition to or alternative to FAS inhibition.
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