SLPI KNOCKOUT MICE AND METHODS FOR WOUND TREATMENT

摘要

The invention provides a transgenic non-human animal having a functional disruption in an endogenous SLPI gene. According to the invention, the disruption results in impaired wound healing, reduced defense to pathogens, pathogenic response to antigen induced asthma, or a pathogenic inflammatory response. The invention also provides methods for making the transgenic non-human animal. The transgenic non-human animal can be used as a model for disease states including inflammation, for example, asthma, wound healing, etc. and to screen for therapeutic agents for treating the same. The invention also provides a method for treating inflammation, by administering SLPI peptide.