ANGIOSTATIN AND ENDOSTATIN BINDING PROTEINS AND METHODS OF USE

摘要

The present invention is related to compositions and methods for the modulation of angiogenesis.In particular, the present invention includes Angiostatin and Endostatin binding peptides and proteins and methods of using the same. The present invention identifies tropomyosin protein as an Endostatin binding protein and a laminin beta-1 chain as an Angiostatin binding protein. The present invention also provides methods of inhibiting angiogenesis in an individual comprising administering to the individuala tropomyosin binding compound and/or an actin cytoskeleton disrupting compound.