PANCREATIC LANGERHANS β CELL PROLIFERATION PROMOTER AND APOPTOSIS INHIBITOR, AND SCREENING OF CANDIDATE COMPOUNDS FOR THE E DRUGS

摘要

It is indicated that the expression of Reg gene in ß cells can be remarkably induced and thus the proliferation of ß cells can be promoted by using an inflammation transmitter IL-6 together with glucocorticoid. It is also indicated that HGF inhibits apoptosis induced by Reg protein and that IL-6 and glucocorticoid induce the expression of HGF gene in cells. PARP inhibitors such as nicotinic acid amide and 3-aminobenzamide further enhance the induction of the expression of these genes. Moreover, the expression induction mechanism is analyzed by using the promoter regions of Reg gene and HGF gene and a method of efficiently screening candidate compounds for these gene expression inducers is developed.