HUMAN G PROTEIN-COUPLED RECEPTOR IGPcR20, AND USES THEREOF

摘要

A novel human G protein-coupled receptor (GPcR) protein, IGPcR20, is identified and characterized. IGPcR20-encoding nucleotides, IGPcR20 proteins and fusion proteins, antibodies to the receptor, host cell expression systems, animal models in which the IGPcR20 gene is mutated, recombinant knock-out animals that do not express IGPcR20 and transgenic animals that express an IGPcR20 transgene are encompasssed by the invention, as are compounds that modulate gene expression or receptor activity of IGPcR20 and their use for drug screening, and diagnosis or treatment of diseases and disorders, particularly cancer, reproductive disorders and infertility related to epididymal dysfunction.