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POLYMORPHIC HUMAN GABA A RECEPTOR ALPHA-6 SUBUNIT
POLYMORPHIC HUMAN GABA A RECEPTOR ALPHA-6 SUBUNIT
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机译:多态人类GABA受体ALPHA-6的亚基
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摘要
Compositions and methods based on a polymorphism in the gene encoding the α6 subunit of the human GABAA neurotransmitter receptor are disclosed. This polymorphism results in the substitution of a serine residue for a proline residue ordinarily present at amino acid position 385 of the α6 polypeptide sequence. Significantly, the polymorphism was associated with decreased sensitivity to ethanol and benzodiazepine drugs.
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