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Polymorphic human GABAA receptor alpha-6 subunit
Polymorphic human GABAA receptor alpha-6 subunit
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机译:人类GABAA受体多态性alpha-6亚基
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摘要
Compositions and methods based on a polymorphism in the gene encoding the 6 subunit of the human GABAA neurotransmitter receptor are disclosed. This polymorphism results in the substitution of a serine residue for a proline residue ordinarily present at amino acid position 385 of the 6 polypeptide sequence. Significantly, the polymorphism was associated with decreased sensitivity to ethanol and benzodiazepine drugs.
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机译:公开了基于编码人GABA A Sub>神经递质受体的6个亚基的基因中的多态性的组合物和方法。这种多态性导致丝氨酸残基被通常存在于6个多肽序列的氨基酸位置385处的脯氨酸残基取代。显着地,多态性与对乙醇和苯二氮卓类药物的敏感性降低有关。
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