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NG2/HM PROTEOGLYCAN-BINDING PEPTIDES THAT HOME TO ANGIOGENIC VASCULATURE AND RELATED METHODS
NG2/HM PROTEOGLYCAN-BINDING PEPTIDES THAT HOME TO ANGIOGENIC VASCULATURE AND RELATED METHODS
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机译:NG2 / HM糖原结合肽作为血管生成血管的原位及其相关方法
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摘要
The present invention provides angiogenic vasculature homing molecules that bind to NG2/HM proteoglycan, including, for example, a peptide comprising the amino acid sequence TAASGVRSMH (SEQ ID NO:1) or LTLRWVGLMS (SEQ ID NO:2). The invention also provides conjugates comprising an angiogenic vasculature homing molecule linked to a moiety such as a drug, a cytotoxic agent, a chemotherapeutic agent, or a detectable agent. The invention additionally provides a method of targeting angiogenic vasculature in a tumor in vivo by contacting the angiogenic vasculature with an angiogenic vasculature homing molecule that selectively homes to a NG2/HM proteoglycan, wherein the angiogenic vasculature homing molecule is not an antibody. The invention additionally provides a method of inhibiting angiogenesis in a tumor of a subject by administering to the subject a conjugate comprising a moiety linked to an angiogenic vasculature homing molecule that selectively binds a NG2/HM proteoglycan, wherein the angiogenic vasculature homing molecule is not an antibody.
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机译:本发明提供了与NG2 / HM蛋白聚糖结合的血管生成脉管归巢分子,包括例如包含氨基酸序列TAASGVRSMH(SEQ ID NO:1)或LTLRWVGLMS(SEQ ID NO:2)的肽。本发明还提供了包含与诸如药物,细胞毒性剂,化学治疗剂或可检测剂的部分连接的血管生成脉管系统归巢分子的缀合物。本发明还提供了通过使血管生成脉管与选择性地归巢于NG2 / HM蛋白聚糖的血管生成脉管归巢分子接触而在体内靶向肿瘤中的血管生成脉管系统的方法,其中该血管生成脉管归巢分子不是抗体。本发明还提供了通过向受试者施用包含与血管生成血管系统归巢分子连接的部分的缀合物来抑制受试者肿瘤中血管生成的方法,该缀合物选择性地结合NG2 / HM蛋白聚糖,其中血管生成血管系统归巢分子不是抗体。
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