MHC class II transactivator (CIITA) and uses thereof

摘要

Genes coding for transacting proteins being essential for the general control of vertebrate MHC class II gene expression, proteins encoded by these genes and a method for the identification of such transacting proteins are disclosed. Furthermore, substances that allow the reduction of aberrant expression of said genes are disclosesd. Still further, recombinant vectors comprising said genes, transformed host organisms and methods for the production of the proteins encoded by said genes are disclosed.;The invention also discloses pharmaceutical compositions useful for the treatment of diseases associated with impaired or aberrant expression of MHC class II genes.