METHODS OF USE OF REGULATORS OF G-PROTEIN SIGNALING TO MODULATE DOPAMINE SIGNALING AND DOPAMINE-RELATED NEUROBEHAVIOR

摘要

The invention relates to an animal model for studying behavior related to RGS9 and RGS9 modulated dopamine D2-mediated behavior. The invention provides transgenic non-human animals in which RGS9 expression is disrupted, methods of using such animals, and methods of modulating dopamine D2-mediated behavior.