METHOD FOR THE ENANTIOSELECTIVE PREPARATION OF ADDUCTS OF $G(A)-SUBSTITUTED PHENYLETHYLAMINE-CYCLOALKANES AND OF 2-ACETOXYACRYLONITRILE, INTERMEDIATES IN THE ENANTIOSELECTIVE SYNTHESIS OF THE LATERAL CHAIN OF HARRINGTONINES

摘要

The invention relates to a method for the enantioselective preparation of adducts of α-substituted phenylethylimino-cycloalkanes and of 2-acetoxyacrylonitrile with the formula (I), wherein the carbon atom in position 1' has the stereochemistry 1'S or 1'R; n = 0 to 3; Z is a protected alcohol radical having the formula OGP1; GP1 is a protective group such as a carbon-containing ether, a silylated ether or an ester; GP2 is a protective group of enols such as a silylated ether; and involving a Michael reaction between the methyl cyanoacetate and a chiral imine.