METHOD OF ENANTIOSELECTIVE SYNTHESIS OF INTERMEDIATE COMPOUNDS USED IN SYNTHESIS OF FLAVONE-SUBSTITUTED PYRROLIDINES

摘要

FIELD: chemistry.;SUBSTANCE: invention relates to enantioselective synthesis of intermediate compounds, specifically (-)-trans-(1-methyl-3-(2,4,6-trimethoxyphenyl) pyrrolidin-2-yl)methanol of formula A ; involving steps on which (-)-trans-1-methyl-5-oxo-3-(2,4,6-trimethoxyphenyl)pyrrolidin-2-carboxylic acid of formula E is treated with a reducing agent in a solvent. These compounds are used in synthesis of the (+)-trans enantiomer of pyrrolidines substituted with flavones, having formula 1 , or salts thereof which are cycline-dependant kinase inhibitors and can be used to treat proliferative disorders such as cancer.;EFFECT: method allows efficient large-scale synthesis of the compound by excluding the racemate splitting technique.;15 cl, 12 ex