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FADD-LIKE ANTI-APOPTOTIC MOLECULES, METHODS OF USING THE SAME, AND COMPOSITIONS FOR AND METHODS OF MAKING THE SAME
FADD-LIKE ANTI-APOPTOTIC MOLECULES, METHODS OF USING THE SAME, AND COMPOSITIONS FOR AND METHODS OF MAKING THE SAME
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机译:相似的抗凋亡分子,使用相同的方法以及相同的组成和方法
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摘要
Two FADD-like anti-apoptotic proteins FLAME-1 and FLAME-2 that regulate Fas/TNFR1- or UV-induced apoptosis are disclosed. Nucleotide sequences encoding the proteins are disclosed as are methods of using the nucleic acid molecules and making the proteins. Pharmaceutical compositions and methods of using the same are disclosed. Reagents, kits and methods of identifying compounds that inhibit anti-apoptotic activity of the proteins and methods of identifying compounds that inhibit binding activity of the proteins are disclosed.
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