BETA-ENDORPHIN/CRF GENE THERAPY FOR LOCALLY COMBATING PAIN

摘要

The invention relates to an agent for calming the sensation of pain, in particular in chronic inflammatory disorders, by the expression of endogenic, neuroendocrine peptides at the inflammation site. The invention relates in particular to the expression of POMC or CRF from locally injected DNA expression constructs, preferably covalently peptide-modified expression constructs.