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TREATMENTS FOR NEUROTOXICITY IN ALZHEIMER'S DISEASE BY beta-AMYLOID PEPTIDES
TREATMENTS FOR NEUROTOXICITY IN ALZHEIMER'S DISEASE BY beta-AMYLOID PEPTIDES
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机译:β-淀粉样肽治疗老年痴呆症的神经毒性
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摘要
The invention involves identification of a mechanism of β-amyloid peptide cytotoxicity, which enables treatment of conditions caused by β-amyloid peptide aggregates by administration of compounds which antagonize the mechanism of cytoxicity. The invention includes the identification and isolation of compounds which can antagonize the aggregation of β-amyloid peptides and the neurotoxic effects of such aggregates. The compounds include isolated peptides which were selected for their ability to form a complex with a β-amyloid peptide, or are derived from peptides so selected. Methods for treating conditions resulting from neurotoxic β-amyloid peptide aggregates and pharmaceutical preparations are provided. Also provided are methods for selecting additional compounds which can antagonize the aggregation of β-amyloid peptides and the neurotoxic effects of such aggregates.
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