COMPOSITIONS AND METHODS FOR TRANSEPITHELIAL TRANSPORT OF MEMBRANE-BOUNDED VESICLES AND VIRIONS

摘要

The invention provides compositions and methods for the delivery of membrane-bounded vesicles such as liposomes and the virions of enveloped viruses, as well as nucleocapsid virions into, through, out of and around, epithelial cells and layers and, optionally, to an intracellular location. Such membrane-bounded vesicles and virions are used to deliver therapeutic agents in general. Certain aspects of the invention are particularly well suited for the delivery of therapeutic nucleic acids, i.e., gene therapy.