(Poly)peptides for the preparation of vaccines against Bordetella pertussis and/or Bordetella parapertussis, vaccines based upon such (poly)peptides, and antibodies against such peptides

摘要

The invention relates to a peptide comprising:a) between 6 and 40 contiguous amino acid residues from the amino acid sequence of "region 1" of a Bordetella pertussis pertactin; andb) a total of between 6 and 100, preferably between 6 and 50 amino acid residues; or an analog of such a peptide; optionally in the form of a salt acceptable for pharmaceutical and/or veterinary purposes.;The invention also relates to a polypeptide having the amino acid sequence of a pertactin from which, compared to the sequence of said pertactin:a) the amino acid residues that form the so-called "region 1" have been at least partly, and preferably essentially completely removed; and/or from which,b) the amino acid residues that form the so-called "region 2" have been at least partly, and preferably essentially completely removed.;The invention further relates to a pharmaceutical composition, and in particular a vaccine against (at least) Bordetella pertussis and/or Bordetella parapertussis, comprising the peptide and/or the polypeptide mentioned above.;Also, the invention comprises an antibody, generated/elicited against such a peptide and/or polypeptide, and to a pharmaceutical and/or veterinary composition comprising such an antibody.