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METHODS FOR DETECTION OF NUCLEIC ACID POLYMORPHISMS USING PEPTIDE-LABELED OLIGONUCLEOTIDES AND ANTIBODY ARRAYS
METHODS FOR DETECTION OF NUCLEIC ACID POLYMORPHISMS USING PEPTIDE-LABELED OLIGONUCLEOTIDES AND ANTIBODY ARRAYS
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机译:肽标记的寡核苷酸和抗体阵列检测核酸多态性的方法
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摘要
The present invention is directed to methods and compositions for use in screening nucleic acid populations for nucleic acid polymorphisms. The methods, referred to generally as ValiGeneSM Mutation Screening, Peptide-Linked (VGMS-PL) methods, are specifically designed for high-throughput genotype mapping and gene expression analysis of animal and plant nucleic acids without requiring a PCR amplification step. In particular, the methods of the invention utilize oligonucleotide probes labeled with distinguishable and identifiable peptide tags, that are captured on addressable antibody arrays.
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