OUTER MEMBRANE PROTEIN A, PEPTIDOGLYCAN-ASSOCIATED LIPOPROTEIN, AND MUREIN LIPOPROTEIN AS THERAPEUTIC TARGETS FOR TREATMENT OF SEPSIS

摘要

The present invention relates to three outer membrane proteins conserved among Gram-negative bacteria, OmpA, PAL, and MLP. The invention provides vaccines and polypeptides useful for passive and active immunization against Gram-negative bacteria, as well as methods of preventing and treating Gram-negative sepsis.