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Process for preparing 2-(4-trifluoromethoxyphenyl)ethylamine and 4-bromomethyl- and 4-chloromethyl- -1trifluoromethoxybenzene
Process for preparing 2-(4-trifluoromethoxyphenyl)ethylamine and 4-bromomethyl- and 4-chloromethyl- -1trifluoromethoxybenzene
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机译:制备2-(4-三氟甲氧基苯基)乙胺和4-溴甲基-和4-氯甲基-1三氟甲氧基苯的方法
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摘要
2- (4-Trifluoromethoxyphenyl) ethylamine can be produced in an advantageous manner if trifluoromethoxybenzene is converted into halomethyl-1-trifluoromethoxybenzene by halogenomethylation, this compound is converted into 4- (trifluoromethoxyphenyl) acetonitrile by a halogen-cyano exchange finally reduced with hydrogen in the presence of a nickel catalyst. The first stage of this process also represents an advantageous process for the preparation of 4-bromomethyl and 4-chloromethyl-1-trifluoromethoxy-benzene.
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