SUBSTANCE CAPABLE OF CONTROLLING THE INCLUSION OF EXON 10 OF THE TAU GENE, AND ITS THERAPEUTIC USE AGAINST TAUOPATHIES

摘要

The present inventions relates to substances which are capable of controlling the inclusion of exon 10 of the tau gene. The substances can reverse "wrong" tau splicing pattern and. Since "wrong" tau splicing patterns are associated with tauopathies that cause dementia, the substances can be used as therapeutic agents. The invention also provides a method for testing substances that control tau exon 10 inclusion. The method is suitable for a high throughput screening. Additional products which are useful for changing tau exon 10 expression or for performing the test method are described as well.