-2 RETROVIRUS VECTOR CONTAINING TISSUE INHIBITOR OF METALLOPROTEINASE-2 GENE CELL LINE PRODUCING RETROVIRUS CONTAINING SAID VECTOR AND ANTICANCER COMPOSITION CONTAINING SAID CELL LINE

摘要

PURPOSE: A retrovirus vector comprising tissue inhibitor of metalloproteinase-2 (TIMP-2), a cell line containing the vector and an anticancer composition containing the same cell line are provided, which retrovirus vector can insert TIMP-2 gene into human cancer cells, so that the growth and transition of cancer cells can be inhibited. CONSTITUTION: The retrovirus vector pLNC/TIMP-2/IRES/TK comprises the tissue inhibitor of metalloproteinase-2(TIMP-2) gene, the internal ribosome entry site(IRES) sequence and Herpes simplex virus thymidine kinase gene(HSV-tk). The cell line PG13/LNC/TIMP-2/IRES/TK (KCTC 0777BP) is produced by transforming with the retrovirus vector pLNC/TIMP-2/IRES/TK. The anticancer composition contains the cell line PG13/LNC/TIMP-2/IRES/TK (KCTC 0777BP) and its pharmaceutically acceptable carrier.