3--1--1-124 NOVEL BRANCHED SUBSTITUTED AMINO DERIVATIVES OF 3-AMINO-1-PHENYL-1H-124TRIAZOLE PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPR1SING THEM

摘要

The present invention relates to compounds of formula (I);(I);(Wherein,;R ₁ , R ₂ and R ₃ independently of one another are hydrogen, halogen atom, (C ₁ -C ₅ ) alkyl, (C ₁ -C ₅ ) alkoxy, trifluoromethyl or SR group, and ₁ -C ₅₎ alkyl),;R ₄ and R ₅ is (C ₁ -C ₅₎ alkyl, an alkynyl of 3 to 5 carbon atoms carbonyl, (C ₃ -C ₅₎ cycloalkyl (C ₁ -C ₃₎ alkyl, or R _a -X- (C ₁ -C ₂ ) alkyl group wherein R _a is (C ₁ -C ₃ ) alkyl and X is O,;R ₆ is -CHR ₇ &_gt; R &;R ₇ is (C ₃ -C ₅ ) cycloalkyl, a phenyl group in which the 3, 4 or 5 position can be replaced by one or more Z 'radicals, wherein the Z' radical is halogen, (C ₁ - C ₁ -C ₅ ) alkyl, (C ₁ -C ₅ ) alkyl-X- or (C ₁ -C ₃ ) alkyl-X- (C ₁ -C ₂ ) alkyl wherein X is O, methylenedioxy) ,ego;R ₈ is (C ₁ -C ₆₎ alkyl, (C ₃ -C ₅₎ cycloalkyl (C ₁ -C ₃₎ alkyl, (C ₁ -C ₃₎ alkyl, -X- (C ₁ -C ₃₎ alkyl ( Wherein X is O);This compound is useful as a CRF receptor.