Process for preparative resolution of metoprolol enantiomer

摘要

The invention metoprolol La added racemate to a method for producing a metoprolol enantiomer (enantiomer) from (metoprolol racemate), specifically, 1) metoprolol la optical isomers reagent to racemates MCF (menthyl chloroformate) (± ) to obtain a stereo Murray (diastereomers) in the die; 2) (±) - stereo die a mixture Murray HPLC (high performance liquid chromatography) (+), (using a on-) comprising: a stereo separation meoro the die; 3) the separated (+), (-) - hydrolyzing the stereo stayed in the die is configured to obtain the enantiomer, compared with the conventional asymmetric synthesis method (asymmetric synthesis) or chiral chromatography (chiral chromatography) racemisation (racemization) is represented as a high yield in a simple and quick way, as well how to get metoprolol enantiomer of high purity and economically without.