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3 Method for assaying hepatitis C virus NS3 protease and inhibitor thereof by using fluorescence resonance energy transfer
3 Method for assaying hepatitis C virus NS3 protease and inhibitor thereof by using fluorescence resonance energy transfer
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机译:3利用荧光共振能量转移法测定丙型肝炎病毒NS3蛋白酶及其抑制剂的方法
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摘要
The present invention relates to an enzyme activity of a non-structural protein 3 of hepatitis C virus and a method for measuring the inhibitory activity of the inhibitory compound. More specifically, the present invention relates to a novel fluorescent resonance energy Transition (hereinafter abbreviated as " FRET ")substrate; A method of measuring the enzyme activity of the non-structural protein 3 of the hepatitis C virus and the inhibitory activity of the inhibitory compound against the non-structural protein 3 using the FRET substrate; And a method for screening and screening an activity inhibitor of hepatitis C virus nonstructural protein 3 using the above method, and more particularly, to a method for screening and screening an activity inhibitor of hepatitis C virus non-structural protein 3 using the FRET substrate according to the present invention, The enzyme activity and the inhibitory activity of the inhibitory compound thereof can be measured, and the method according to the present invention can ultimately be used to develop a therapeutic agent for hepatitis C virus.
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