ENDOTHELIN ANTAGONISTS: N-2'-(4,5-DIMETHYL-3-ISO-XAZOLYL)AMINOSULFONYL- 4-(2-OXAZOLYL)1,1'-BIPHENYL-2-YLMETHYL-N,3,3-TRIMETHYLBUTANEAMIDE AND N-(4,5-DIMETHYL-3-ISOXAZOLYL)-2'-(3,3-DIMETHYL-2-OXO-1- PYRROLIDINYL)METHYL-4'-(2-OXAZOLYL)1,1'-BIPHENYL-2-SULFONEAMIDE AND THEIR SALTS

摘要

FIELD: organic chemistry. SUBSTANCE: invention relates to compounds: N-[[2'-[[(4,5-dimethyl-3-isoxazolyl)amino] sulfonyl] -4-(2-oxazolyl) -[1,1'- biphenyl] -2-yl] methyl]-N,3,3-trimethylbutaneamide and N-(4,5-dimethyl-3-isoxazolyl)-2'-[(3,3-dimethyl-2-oxo-1-yrrolidinyl)methyl] -4'-(2-oxazolyl)[1,1'-biphenyl] -2-sulfoneamide and their pharmaceutically acceptable salts, for example, lithium, sodium or potassium salt or salt with a base that is an organic amine. These compounds can be used as endothelin antagonists. EFFECT: synthesis of novel compounds as antagonists of endothelin. 15 cl, 2 tbl, 5 ex