Endothelin antagonists: N-2'-(4,5-dimethyl-3-isoxazolyl)aminosulfonyl-4-(2-oxazolyl)1,1'-biphenyl-2-ylmethyl-N,3,3-trimethylbutanamide and N-(4,5-dimethyl-3-isoxazolyl)-2'-(3,3-dimethyl-2-oxo-1-pyrrolidinyl)methyl-4'-(2-oxazolyl)1,1'biphenyl-2-sulfonamide and salts thereof.

摘要

The compounds N-[[2'-[[(4,5-dimethyl-3-isoxazolyl)amino]sulfonyl]-4-(2-oxazolyl)[1,1'-biphenyl]-2-yl]methyl]-N,3,3-trimethylbutanamide and N-(4,5-dimethyl-3-isoxazolyl)-2'-[(3,3-dimethyl-2-oxo-1-pyrrolidinyl)methyl]-4'-(2-oxazolyl)[1,1'-biphenyl]-2-sulfonamide, and salts thereof, useful as endothelin antagonists.