DERIVATIVES OF 6-ARYLPYRIDO2,3-DPYRIMIDINES AND -NAPHTHYRIDINES, PHARMACEUTICAL COMPOSITION SHOWING INHIBITORY EFFECT ON CELLULAR PROLIFERATION INDUCED BY PROTEIN TYROSINE KINASE AND METHOD OF INHIBITION OF CELLULAR PROLIFERATION

摘要

FIELD: organic chemistry, heterocyclic compounds, biochemistry, pharmacy. SUBSTANCE: invention relates to novel derivatives of 6-arylpyrido[2,3-d]pyrimidine and naphthyridine, their pharmaceutically acceptable salts, a pharmaceutical composition showing an inhibitory effect on cellular proliferation induced by protein tyrosine kinase and a method of inhibition of cellular proliferation. Indicated properties of compounds will ensure to use their in the important biological processes in pathological mechanism and proliferative diseases, for example, cancer, atherosclerosis and restenosis. The proposed compounds correspond to the general formula (I) where X means methine group or nitrogen atom; B means the group NR₃R₄; each of R₁,R₂,R₃,R₄ means independently hydrogen atom, alkyl with 1-8 carbon atoms or residue Ar, or the group (A) , and their pharmaceutically acceptable salts. Invention relates to also a pharmaceutical composition comprising at least one pharmaceutical carrier and a compound of the formula (I) as an active substance or its a pharmaceutically acceptable salt taken in effective amount and to a method of inhibition of cellular proliferation induced by protein tyrosine kinase by administration of a compound of the formula (I) in effective dose or its pharmaceutically acceptable salt in effective dose. EFFECT: new compounds indicated above, valuable medicinal properties. 46 cl, 2 tbl, 131 ex