New mRNA indicative of T cell activation and functional status, useful for diagnosis and therapy e.g. of autoimmunity or transplant rejection

摘要

Messenger RNA, (mRNA), (I), for use as indicator of the activation and functional status of T cells, that have increased or reduced expression, and are present at higher or lower concentration, in activated T cells, relative to normal or resting cells, where (I) hybridizes to any of 334 sequences, reproduced, or their derivatives, complements or fragments, is new. Independent claims are also included for the following: (a) polynucleotides (II) with any of the 334 specified sequences (or their derivatives, complements or fragments that hybridize to them) for use as reagent for determining the activation or functional status of T cells; (b) polypeptides (III) derived from (II); (c) reagent for determining the activation or functional status of T cells comprising (II); (d) recombinant DNA vector molecules (IV) containing one or more (II) and transcribable in T cells; (e) antibody (Ab) specific for (III); and (f) binding molecules (IV) that react specifically with (II).